Scientific Articles5 The review of Delivering mRNA to a human NK cell line, NK-92 cells, by lipid nanoparticles Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are immune cells known for their lethal capabilities. CTLs develop from naïve CD8+ T cells, acquiring antigen peptides from dendritic cells (DCs), enabling potent, antigen-specific killing, and forming immunological memory. CTLs' specificity and memory play vital roles in viral infection vaccinations. In cancer immunity, CTLs are key p.. 2023. 8. 11. The review of Self-assembled nanoparticles: A new platform for revolutionizing therapeutic cancer vaccines Over the past decade, cancer vaccines have achieved noteworthy advancements. Through a comprehensive analysis of tumor antigen genomics, numerous therapeutic vaccines have advanced into clinical trials for various cancers, such as melanoma, lung cancer, and head and neck squamous cell carcinoma. These trials have showcased remarkable tumor immunogenicity and anti-tumor activity. Notably, a recen.. 2023. 8. 11. The review of Self-assembled nanoparticles: A new platform for revolutionizing therapeutic cancer vaccines Over the past decade, cancer vaccines have achieved noteworthy advancements. Through a comprehensive analysis of tumor antigen genomics, numerous therapeutic vaccines have advanced into clinical trials for various cancers, such as melanoma, lung cancer, and head and neck squamous cell carcinoma. These trials have showcased remarkable tumor immunogenicity and anti-tumor activity. Notably, a recen.. 2023. 8. 10. The review of Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response Summary Achieving precise delivery of messenger RNA(mRNA) to specific organs remains a significant challenge for the practical application of mRNA technology in vivo. In the context of mRNA vaccines, targeting delivery to the lymph node(LN) holds the promise of reducing side effects while enhancing the immune response. In this study, we investigated an endogenous LN-targeting lipid nanoparticle(.. 2023. 8. 9. 이전 1 2 다음
